Synthesis and study the anti-proliferative effect of new series of 1H-imidazo[4,5-c]quinoline derivatives in MCF-7 (human breast cancer) cells
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Date
2015-06
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VIT University
Abstract
Breast cancer is the most prevalent form of cancer in
women world over. MCF-7 cells are useful for in vitro
breast cancer studies because the cell line has retained
several ideal characteristics particular to the mammary
epithelium. These include the ability for MCF-7 cells to
process estrogens, in the form of estuarial, via estrogens
receptors in the cell cytoplasm. This makes the MCF-7
cell line an estrogens receptor (ER) positive control cell
line. In breast cancer cells containing oestrogen receptors
both oestrogens and growth factors can stimulate proliferation, invasion and the secretion of a number of proteins.